Guangxitoxin 1E ( —— )

产品货号. M30230 CAS No. 1233152-82-3

Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货

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生物学信息

产品名称

Guangxitoxin 1E
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.
产品描述

Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials. (In Vitro):Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM but has no significant effect on KV1.2, KV1.3, KV1.5, KV3.2 and BK potassium channels, nor on calcium and sodium channels CaV1.2, CaV2.2, NaV1.5, NaV1.7, NaV1.8, whereas the IC50 for KV4.3 channels is 24-54 nM. In mouse β-cells, Guangxitoxin 1E inhibits 90% of IDR and, as for KV2.1, shifts the voltage dependence of channel activation to more depolarized potentials, a characteristic of gating-modifier peptides. Guangxitoxin 1E broadens theβ-cell action potential, enhances glucose-stimulated intracellular calcium oscillations, and enhances insulin secretion from mouse pancreatic islets in a glucose-dependent manner.
体外实验

Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM but has no significant effect on KV1.2, KV1.3, KV1.5, KV3.2 and BK potassium channels, nor on calcium and sodium channels CaV1.2, CaV2.2, NaV1.5, NaV1.7, NaV1.8, whereas the IC50 for KV4.3 channels is 24-54 nM.In mouse β-cells, Guangxitoxin 1E inhibits 90% of IDR and, as for KV2.1, shifts the voltage dependence of channel activation to more depolarized potentials, a characteristic of gating-modifier peptides. Guangxitoxin 1E broadens theβ-cell action potential, enhances glucose-stimulated intracellular calcium oscillations, and enhances insulin secretion from mouse pancreatic islets in a glucose-dependent manner.
体内实验

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同义词

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通路

Cell Cycle/DNA Damage
靶点

Potassium Channel
受体

IC50: 1-3 nM (KV2 channels); 24-54 nM (KV4.3 channels)
研究领域

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适应症

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化学信息

CAS Number

1233152-82-3
分子量

3948.61
分子式

C178H248N44O45S7
纯度

>98% (HPLC)
溶解度

In Vitro:? H2O : ≥ 1 mg/mL (0.25 mM)
SMILES

——
化学全称

Sequence:{Glu}{Gly}{Glu}{Cys}{Gly}{Gly}{Phe}{Trp}{Trp}{Lys}{Cys}{Gly}{Ser}{Gly}{Lys}{Pro}{Ala}{Cys}{Cys}{Pro}(Disulfide bridge: Cys4-Cys19; Cys11-Cys24; Cys18-Cys31)

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

H?nigsperger C, et al. Physiological roles of Kv2 channels in entorhinal cortex layer II stellate cells revealed by Guangxitoxin-1E. J Physiol. 2017 Feb 1;595(3):739-757.

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